A systematic review of subcutaneous versus intramuscular or intravenous routes of opioid administration on pain outcomes in cancer and post-surgical clinical …

L Fairbairn, A Schuberth, L Deacon… - … Journal of Pain, 2023 - journals.sagepub.com
Cancer pain One-way cross-over trial 39 18 SC bolus IV … cross-sectional study – the
within-patient design mitigated confounding … SC morphine to be superior to IM morphine. …

Pharmacy-led quality improvement project on pain control using continuous subcutaneous infusion of opioids in an inpatient hospice unit

NM Romero, S DiScala, J Quellhorst… - American Journal of …, 2020 - journals.sagepub.com
… The study was designed as a one-way crossover within patients in which each patient received
continuous IV infusion and then continuous SC … The mean stable SC dose of morphine (…

Revision of pharmacological treatment recommendations for cancer pain: clinical guidelines from the Japanese Society of Palliative Medicine

H Mawatari, T Shinjo, T Morita, H Kohara… - Journal of Palliative …, 2022 - liebertpub.com
continuous intravenous or subcutaneous injection for rapid … of morphine between subcutaneous
injection and intravenous … relief of severe cancer pain: A double-blind, crossover trial. …

Efficacy of continuous intrathecal infusion trialing with a mixture of fentanyl and bupivacaine in chronic low back pain patients

SM Hayek, BA Jones, E Veizi, TQ Tran… - Pain …, 2023 - academic.oup.com
… scale and the within-patient standard deviation is 5 [15–17]. … A prospective study examining
low doses morphine in IDD … In conclusion, this double-blind randomized crossover study

Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies

S Nielsen, L Picco, B Murnion, B Winters… - …, 2022 - nature.com
… double-blind within-patient study designs (Table 2a). Four … of dronabinol and morphine
resulted in reduced pain “… In contrast, a double-blind crossover study in sickle cell patients found …

[HTML][HTML] Optimizing and accelerating the development of precision pain treatments for chronic pain: IMMPACT review and recommendations

RR Edwards, KL Schreiber, RH Dworkin, DC Turk… - The journal of pain, 2023 - Elsevier
… In a more recent enrichment-design, placebo-controlled crossover trial of pregabalin for
the treatment of prediabetic neuropathic pain, pretreatment IENFD was associated with …

Evaluation of efficacy and safety of subcutaneous acetaminophen in geriatrics and palliative care (APAPSUBQ)

J El Khoury, S Hlais, M Helou, MC Mouhawej… - BMC Palliative Care, 2022 - Springer
… These results agree with the data on oral and IV … treated with acetaminophen + morphine
or acetaminophen + … pain relievers and those with moderate to severe uncontrolled or acute …

Tramadol for chronic pain in adults: protocol for a systematic review with meta-analysis and trial sequential analysis of randomised clinical trials

J Barakji, SK Korang, JB Feinberg, M Maagaard… - Systematic …, 2023 - Springer
… For trials using a crossover design, only data from the first … the within-patient anchor-based
method, while the median in … other pain-reducing interventions, eg other morphine products …

… continuous peripheral nerve blocks to treat postamputation phantom limb pain: a multicenter, randomized, quadruple-masked, placebo-controlled clinical trial

BM Ilfeld, B Khatibi, K Maheshwari, SJ Madison… - Pain, 2021 - journals.lww.com
… the catheter, the catheter tunneled subcutaneously, and the catheter … results, although the
comparisons are made within patient. … Due to the crossover design, we were not able to directly …

Ketamine for refractory chronic pain: a 1-year follow-up study

A Corriger, M Voute, C Lambert, B Pereira, G Pickering… - Pain, 2022 - journals.lww.com
… /day once a week for 8 weeks, intravenous or subcutaneous). Every … within-patient variability.
To compare changes between groups, group x time-point evaluation interaction was studied